Breast Cancer | Melinda Telli, MD

Breast Cancer Update, Issue 4, 2019 — Part 2: Our interview with Dr Telli highlights the following topics as well as cases from her practice: Case: A woman in her early 50s with de novo metastatic TNBC is enrolled on the IMpassion130 trial evaluating atezolizumab with nab paclitaxel (00:00) Initial workup and genetic testing for patients with metastatic TNBC (02:33) Risk of recurrence for patients with localized TNBC; patterns of metastasis (05:11) Approach to PD-L1 testing for patients with TNBC (07:29) Results of the Phase III IMpassion130 study of atezolizumab with nab paclitaxel for previously untreated advanced TNBC (10:41) Clinical implications of the IMpassion130 study results (14:57) Perspective on progression-free and overall survival outcomes with atezolizumab/nab paclitaxel (16:59) Clinical experience with atezolizumab and nab paclitaxel as first-line therapy for advanced TNBC (19:05) Tolerability of atezolizumab in the IMpassion130 trial (23:52) Activity of single-agent pembrolizumab in patients with TNBC (25:28) Emerging data with pembrolizumab in combination with chemotherapy for TNBC in the (neo)adjuvant setting (27:58) Evaluation of anti-PD-L1 antibodies in the neoadjuvant setting (31:03) Case: A woman in her late 20s with a family history of breast cancer and a germline BRCA mutation receives talazoparib and avelumab on a clinical trial for metastatic TNBC (33:17) Efficacy and tolerability of platinum regimens for patients with TNBC (35:25) Results from the OlympiAD (olaparib) and EMBRACA (talazoparib) trials for patients with HER2-negative advanced breast cancer and a germline BRCA mutation (42:40) Activity and side-effect profile of olaparib versus talazoparib (46:43) Ongoing investigation of the combination of anti-PD-1/PD-L1 antibodies and PARP inhibitors (49:47) Sequencing PARP inhibitors for patients with PD-L1-negative breast cancer (53:03) Use of PARP inhibitors for patients with breast cancer and mutations in DNA damage repair genes beyond BRCA (55:52) Tolerability of PARP inhibitors for patients with germline BRCA mutations (1:00:35) CME information and select publications